Carine Lussier

DSC01694Carine R. Lussier, PhD

PhD Université de Sherbrooke 2010 in Cell Biology

Carine joined the Duchaine Lab as a post-doctoral fellow in the summer of 2010. She pursued an innovative research project to understand how mRNA 3’ UTR isoform variety could be responsible for modulating the response to microRNAs and, in turn, regulate stromal cell paracrine signaling in breast cancer.
Carine was supported in her efforts by a Susan G. Komen postdoctoral fellowship.


1)   Lussier CR, Brial F, Roy SAB, Langlois M-J, Verdu EF, Rivard N, Perreault N and Boudreau F. 2010. Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation. PLoS One. Aug 24;5(8). pii: e12378.

2)   Benoit YD, Lussier C, Ducharme PA, Sivret S, Schnapp LM, Basora N, Beaulieu JF. 2009. Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK- dependent mechanism. Biol Cell. Sep 14;101(12):695-708

3)   Babeu JP, Darsigny M, Lussier CR, Boudreau F. 2009. Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol. Jul;297(1):G124-34. Epub 2009 Apr 23

4)   Lussier CR, Babeu JP, Auclair BA, Perreault N and Boudreau F. 2008. Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a co-culture system. Am J Physiol Gastrointest Liver Physiol. 294(2):G418-28

5)   Boudreau F, Lussier CR, Mongrain,S, Darsigny M, Drouin JL, Doyon G, Suh ER, Beaulieu JF, Rivard N and Perreault N. 2007. Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia. FASEB J. 21(14):3853-65

6)   Garneau H, Alvarez L, Paquin MC, Lussier C, Rancourt C , Tremblay E, Beaulieu JF and Rivard N. 2007. Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 293(4):G758-72

7)   Lussier C, Sodek J and Beaulieu JF. 2001. Expression of SPARC/osteonectin/BM40 in the human gut: Predominance in the stroma of the remodelling distal intestine. J Cell Biochem. 81(3):463-76

8)   Lussier C, Basora N, Bouatrouss Y and Beaulieu JF. 2000. Integrins as mediators of epithelial cell-matrix interactions in the human small intestinal mucosa. Microsc Res Tech. 51(2):169-78