Publications

Take a look at the latest research coming out of our lab!

Flamand MN, Gan HH, Mayya VK, Gunsalus KC, Duchaine TF. A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing. (2017) Nucleic Acids Research. Available online May 8, 2017. doi: 10.1093/nar/gkx340

Wu E, Vashisht A, Chapat C, Flamand MN, Cohen E, Sarov M, Tabach Y, Sonenberg N, Wohlschlegel J, Duchaine TFA continuum of mRNP complexes in embryonic microRNA-mediated silencing. (2016) Nucleic Acids Research. Available online October 3, 2016. doi: 10.1093/nar/gkw872

Izreig S, Samborska B, Johnson RM, Sergushichev A, Ma EH, Lussier C, Loginicheva E, Donayo AO, Poffenberger MC, Sagan SM, Vincent EE, Artyomov MN, Duchaine TF, Jones RG. The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism. (2016) Cell Reports. Available online August 4, 2016. doi: 10.1016/j.celrep.2016.07.036

Flamand MN, Wu E, Vashisht A, Jannot G, Keiper BD, Simard MJ, Wohlschlegel J, Duchaine TFPoly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. (2016) Nucleic Acids Research. Available online April 19, 2016. doi: 10.1093/nar/gkw276

Mayya VK and Duchaine TF. On the availability of microRNA-induced silencing complexes, saturation of microRNA-binding sites and stoichiometry. (2015) Nucleic Acids Research. Available online July 30. doi: 10.1093/nar/gkv720

Foulkes WD, Priest JR, Duchaine TFDICER1: mutations, microRNAs and mechanisms. (2014) Nat Rev Cancer. Oct;14(10):662-72. doi: 10.1038/nrc3802.

Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N. Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1. (2014) RNA. Sep;20(9):1398-409. doi: 10.1261/rna.045302.114.

Kleinman CL, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Quang DA, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso AM, Spence T, Schwartzentruber J, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes JL, Staffa A, Montpetit A, Berube P, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel PM, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor MD, Sladek R, Pastinen T, Chan JA, Huang A, Majewski J, Jabado N. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. (2014) Nat Genet. Jan;46(1):39-44. doi: 10.1038/ng.2849.

Sawh AN and Duchaine TF. A Truncated form of Dicer Tilts the Balance of RNAi Pathways. (2013) Cell Reports. Aug 15;4(3):454-63. doi: 10.1016/j.celrep.2013.07.013.

Flamand M and Duchaine TF. Snapshot: endogenous RNAi machinery and mechanisms. (2012) Cell. Aug 3;150(3):662-662.e2. doi: 10.1016/j.cell.2012.07.016.

Flamand M and Duchaine TF. Snapshot: endogenous RNAi pathways. (2012) Cell. Jul 20;150(2):442-442.e1. doi: 10.1016/j.cell.2012.07.006

Sawh AN and Duchaine TF. Turning Dicer on its head. (2012) Nat Struct Mol Biol. Apr 4;19(4):365-6. doi: 10.1038/nsmb.2275.

Thivierge C, Makil N, Flamand M, Vasale JJ, Mello CC, Wohlschlegel J, Conte D Jr, Duchaine TFTudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. (2011) Nat Struct Mol Biol. Dec 18;19(1):90-7. doi: 10.1038/nsmb.2186

Fabian MR, Cieplak MK, Frank F, Morita M, Green J, Srikumar T, Nagar B, Yamamoto T, Raught B, Duchaine TF, Sonenberg N. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. (2011) Nat Struct Mol Biol. Oct 7;18(11):1211-7. doi: 10.1038/nsmb.2149.

Wu E and Duchaine TFCell-free microRNA-mediated translation repression in Caenorhabditis elegans. (2011) Methods Mol Biol. ;725:219-32. doi: 10.1007/978-1-61779-046-1_15.

Wu E, Thivierge C, Flamand M, Mathonnet G, Vashisht AA, Wohlschlegel J, Fabian MR, Sonenberg N, Duchaine TFPervasive and cooperative deadenylation of 3’UTRs by embryonic microRNA families. (2010) Mol Cell. Nov 24;40(4):558-70. doi: 10.1016/j.molcel.2010.11.003.

Vasale JJ, Gu W, Thivierge C, Batista PJ, Claycomb JM, Youngman EM, Duchaine TF, Mello CC, Conte D Jr. Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. (2010) Proc Natl Acad Sci U S A. Feb 23;107(8):3582-7. doi: 10.1073/pnas.0911908107.

Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W,  Duchaine TF*, Sonenberg N*. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (2009) Mol Cell. Sep 24;35(6):868-80. doi: 10.1016/j.molcel.2009.08.004. *co-corresponding authors

Thomas Duchaine’s publications

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